The following is the list of top 50 major cities in Syria is based on the population and rank along with the capital of the respective state and union territory.
| Rank | City | District | Population |
|---|---|---|---|
| 1 | Aleppo | Mount Simeon District | 2,132,100 |
| 2 | Damascus | Damascus (as a district) | 1,414,913 |
| 3 | Homs | Homs District | 652,609 |
| 4 | Latakia | Latakia District | 383,786 |
| 5 | Hama | Hama District | 312,994 |
| 6 | Ar-Raqqah | Ar-Raqqah District | 220,488 |
| 7 | Deir ez-Zor | Deir ez-Zor District | 211,857 |
| 8 | Al-Hasakah | Al-Hasakah District | 188,160 |
| 9 | Qamishli | Qamishli District | 184,231 |
| 10 | Tartus | Tartus District | 115,769 |
| 11 | Douma | Douma District | 110,893 |
| 12 | Manbij | Manbij District | 99,497 |
| 13 | Idlib | Idlib District | 97,969 |
| 14 | Daraa | Daraa District | 97,969 |
| 15 | Darayya | Darayya District | 78,763 |
| 16 | As-Suwayda | As-Suwayda District | 73,641 |
| 17 | As-Safira | As-Safira District | 63,708 |
| 18 | Al-Bab | Al Bab District | 63,069 |
| 19 | Maarat al-Numaan | Maarat al-Numaan District | 58,008 |
| 20 | Jableh | Jableh District | 53,989 |
| 21 | Palmyra | Palmyra District | 51,323 |
| 22 | Ayn al-Arab | Ayn Al-Arab District | 44,821 |
| 23 | Mayadin | Mayadin District | 44,028 |
| 24 | Abu Kamal | Abu Kamal District | 42,510 |
| 25 | Baniyas | Baniyas District | 41,632 |
| 26 | Jisr ash-Shugur | Jisr ash-Shugur District | 39,917 |
| 27 | Al-Rastan | Ar-Rastan District | 39,834 |
| 28 | Arihah | Arihah District | 39,501 |
| 29 | Afrin | Afrin District | 36,562 |
| 30 | Qatana | Qatana District | 33,996 |
| 31 | Qudsaya | Qudsaya District | 33,571 |
| 32 | An-Nabk | Al-Nabk District | 32,548 |
| 33 | A'zaz | A'zaz District | 31,623 |
| 34 | Al-Qusayr | Al-Qusayr District | 29,818 |
| 35 | Ra's al-'Ayn | Ra's al-'Ayn District | 29,347 |
| 36 | Al-Qutayfah | Al-Qutayfah District | 26,671 |
| 37 | Al-Malikiyah | Al-Malikiyah District | 26,311 |
| 38 | Masyaf | Masyaf District | 22,508 |
| 39 | Harem | Harem District | 21,934 |
| 40 | Izra' | Izra' District | 19,158 |
| 41 | Dayr Hafir | Dayr Hafir District | 18,948 |
| 42 | Mhardeh | Mhardeh District | 17,578 |
| 43 | Duraykish | Duraykish District | 13,244 |
| 44 | Jarabulus | Jarabulus District | 11,570 |
| 45 | Atarib | Atarib District | 10,657 |
| 46 | Qardaha | Qardaha District | 8,671 |
| 47 | Al-Mukharram | Al-Mukharram District | 6,202 |
| 48 | Al-Haffah | Al-Haffah District | 4,298 |
| 49 | Fiq | Fiq District | 1,947 |
| 50 | Quneitra | Quneitra District | 1,024 |
