| Nov 19 2021, Fri | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa ATK Mohun Bagan Vs Kerala Blasters |
| Nov 20 2021, Sat | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Bengaluru Vs NorthEast United |
| Nov 21 2021, Sun | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa SC East Bengal Vs Jamshedpur FC |
| Nov 22 2021, Mon | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Mumbai City Vs Goa |
| Nov 23 2021, Tue | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Hyderabad Vs Chennaiyin FC |
| Nov 24 2021, Wed | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Odisha Vs Bengaluru |
| Nov 25 2021, Thu | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa NorthEast United Vs Kerala Blasters |
| Nov 26 2021, Fri | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Goa Vs Jamshedpur FC |
| Nov 27 2021, Sat | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa SC East Bengal Vs ATK Mohun Bagan |
| Nov 27 2021, Sat | 21:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Mumbai City Vs Hyderabad |
| Nov 28 2021, Sun | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Bengaluru Vs Kerala Blasters |
| Nov 29 2021, Mon | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa NorthEast United Vs Chennaiyin FC |
| Nov 30 2021, Tue | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Odisha Vs SC East Bengal |
| Dec 1 2021, Wed | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa ATK Mohun Bagan Vs Mumbai City |
| Dec 2 2021, Thu | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Jamshedpur FC Vs Hyderabad |
| Dec 3 2021, Fri | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Chennaiyin FC Vs SC East Bengal |
| Dec 4 2021, Sat | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa NorthEast United Vs Goa |
| Dec 4 2021, Sat | 21:30 (IST) | Bambolim Athletic Stadium | Goa | Bengaluru Vs Mumbai City |
| Dec 5 2021, Sun | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Kerala Blasters Vs Odisha |
| Dec 6 2021, Mon | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Jamshedpur FC Vs ATK Mohun Bagan |
| Dec 7 2021, Tue | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa SC East Bengal Vs Goa |
| Dec 8 2021, Wed | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Hyderabad Vs Bengaluru |
| Dec 9 2021, Thu | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Mumbai City Vs Jamshedpur FC |
| Dec 10 2021, Fri | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Odisha Vs NorthEast United |
| Dec 11 2021, Sat | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa ATK Mohun Bagan Vs Chennaiyin FC |
| Dec 11 2021, Sat | 21:30 (IST) | Bambolim Athletic Stadium | Goa | Goa Vs Bengaluru |
| Dec 12 2021, Sun | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa SC East Bengal Vs Kerala Blasters |
| Dec 13 2021, Mon | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Hyderabad Vs NorthEast United |
| Dec 14 2021, Tue | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Odisha Vs Jamshedpur FC |
| Dec 15 2021, Wed | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Mumbai City Vs Chennaiyin FC |
| Dec 16 2021, Thu | 19:30 (IST) | Bambolim Athletic Stadium | Goa | Bengaluru Vs ATK Mohun Bagan |
| Dec 17 2021, Fri | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa NorthEast United Vs SC East Bengal |
| Dec 18 2021, Sat | 19:30 (IST) | Tilak Maidan | Vasco da Gama | Goa Chennaiyin FC Vs Odisha |
| Dec 18 2021, Sat | 21:30 (IST) | Bambolim Athletic Stadium | Goa | Goa Vs Hyderabad |
| Dec 19 2021, Sun | 19:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Mumbai City Vs Kerala Blasters |
| Dec 20 2021, Mon | 19:30 (IST) | JRD Tata Sports Complex Stadium | Jamshedpur | Jamshedpur FC Vs Bengaluru |
| Dec 21 2021, Tue | 19:30 (IST) | Indira Gandhi Stadium | Guwahati | NorthEast United Vs ATK Mohun Bagan |
| Dec 22 2021, Wed | 19:30 (IST) | Jawaharlal Nehru Stadium | Chennai | Chennai Chennaiyin FC Vs Kerala Blasters |
| Dec 23 2021, Thu | 19:30 (IST) | GMC Balayogi Athletic Stadium | Hyderabad | Hyderabad Vs SC East Bengal |
| Dec 24 2021, Fri | 19:30 (IST) | Kalinga Stadium | Bhubaneswar | Odisha Vs Goa |
| Dec 26 2021, Sun | 19:30 (IST) | Jawaharlal Nehru Stadium | Kochi | Kochi Kerala Blasters Vs Jamshedpur FC |
| Dec 27 2021, Mon | 19:30 (IST) | Indira Gandhi Stadium | Guwahati | NorthEast United Vs Mumbai City |
| Dec 28 2021, Tue | 19:30 (IST) | GMC Balayogi Athletic Stadium | Hyderabad | Hyderabad Vs Odisha |
| Dec 29 2021, Wed | 19:30 (IST) | Vivekananda Yuba Bharati Krirangan | Kolkata | ATK Mohun Bagan Vs Goa |
| Dec 30 2021, Thu | 19:30 (IST) | Jawaharlal Nehru Stadium | Chennai | Chennai Chennaiyin FC Vs Bengaluru |
| Jan 2 2022, Sun | 19:30 (IST) | Jawaharlal Nehru Stadium | Kochi | Kochi Kerala Blasters Vs Goa |
| Jan 2 2022, Sun | 21:30 (IST) | JRD Tata Sports Complex Stadium | Jamshedpur | Jamshedpur FC Vs Chennaiyin FC |
| Jan 3 2022, Mon | 19:30 (IST) | Kalinga Stadium | Bhubaneswar | Odisha Vs Mumbai City |
| Jan 4 2022, Tue | 19:30 (IST) | Sree Kanteerava Stadium | Bangalore | Bengaluru Vs SC East Bengal |
| Jan 5 2022, Wed | 19:30 (IST) | Vivekananda Yuba Bharati Krirangan | Kolkata | ATK Mohun Bagan Vs Hyderabad |
| Jan 6 2022, Thu | 19:30 (IST) | JRD Tata Sports Complex Stadium | Jamshedpur | Jamshedpur FC Vs NorthEast United |
| Jan 7 2022, Fri | 19:30 (IST) | Vivekananda Yuba Bharati Krirangan | Kolkata | SC East Bengal Vs Mumbai City |
| Jan 8 2022, Sat | 19:30 (IST) | Vivekananda Yuba Bharati Krirangan | Kolkata | ATK Mohun Bagan Vs Odisha |
| Jan 8 2022, Sat | 21:30 (IST) | Jawaharlal Nehru Stadium | Fatorda | Goa Goa Vs Chennaiyin FC |
| Jan 9 2022, Sun | 19:30 (IST) | Jawaharlal Nehru Stadium | Kochi | Kochi Kerala Blasters Vs Hyderabad |
