The following is the list of top 50 major cities in Mexico is based on the population and rank along with the capital of the respective state and union territory.
| Rank | City | Population (2010) | Municipality | State |
|---|---|---|---|---|
| 1 | Mexico City | 8,851,080 | all 16 boroughs (delegaciones)‡ | Distrito Federal |
| 2 | Ecatepec | 1,655,015 | Ecatepec de Morelos Municipality | México |
| 3 | Guadalajara | 1,495,182 | Guadalajara Municipality | Jalisco |
| 4 | Puebla | 1,434,062 | Puebla Municipality | Puebla |
| 5 | Juárez | 1,321,004 | Juárez Municipality | Chihuahua |
| 6 | Tijuana | 1,300,983 | Tijuana Municipality | Baja California |
| 7 | León | 1,238,962 | León Municipality | Guanajuato |
| 8 | Zapopan | 1,142,483 | Zapopan Municipality | Jalisco |
| 9 | Monterrey | 1,135,512 | Monterrey Municipality | Nuevo León |
| 10 | Nezahualcóyotl | 1,104,585 | Nezahualcóyotl Municipality | México |
| 11 | Culiacán | 905,265 | Culiacán Municipality | Sinaloa |
| 12 | Chihuahua | 809,232 | Chihuahua Municipality | Chihuahua |
| 13 | Naucalpan | 792,211 | Naucalpan de Juárez Municipality‡ | México |
| 14 | Mérida | 777,615 | Mérida Municipality | Yucatán |
| 15 | San Luis Potosí | 722,772 | San Luis Potosí Municipality | San Luis Potosí |
| 16 | Aguascalientes | 722,250 | Aguascalientes Municipality | Aguascalientes |
| 17 | Hermosillo | 715,061 | Hermosillo Municipality | Sonora |
| 18 | Saltillo | 709,671 | Saltillo Municipality | Coahuila |
| 19 | Mexicali | 689,775 | Mexicali Municipality | Baja California |
| 20 | Guadalupe | 673,616 | Guadalupe Municipality | Nuevo León |
| 21 | Acapulco | 673,479 | Acapulco de Juárez Municipality | Guerrero |
| 22 | Tlalnepantla | 653,410 | Tlalnepantla de Baz Municipality | México |
| 23 | Cancún | 628,306 | Benito Juárez Municipality | Quintana Roo |
| 24 | Querétaro | 626,495 | Querétaro Municipality | Querétaro |
| 25 | Chimalhuacán | 612,383 | Chimalhuacán Municipality | México |
| 26 | Torreón | 608,836 | Torreón Municipality | Coahuila |
| 27 | Morelia | 597,511 | Morelia Municipality | Michoacán |
| 28 | Reynosa | 589,466 | Reynosa Municipality | Tamaulipas |
| 29 | Tlaquepaque | 575,942 | Tlaquepaque Municipality | Jalisco |
| 30 | Tuxtla Gutiérrez | 537,102 | Tuxtla Gutiérrez Municipality | Chiapas |
| 31 | Durango | 518,709 | Durango Municipality | Durango |
| 32 | Toluca | 489,333 | Toluca Municipality | México |
| 33 | Ciudad López Mateos | 489,160 | Atizapán de Zaragoza Municipality | México |
| 34 | Cuautitlán Izcalli | 484,573 | Cuautitlán Izcalli Municipality | México |
| 35 | Ciudad Apodaca | 467,157 | Apodaca Municipality | Nuevo León |
| 36 | Matamoros | 449,815 | Matamoros Municipality | Tamaulipas |
| 37 | San Nicolás de los Garza | 443,273 | San Nicolás de los Garza Municipality | Nuevo León |
| 38 | Veracruz | 428,323 | Veracruz Municipality‡ | Veracruz |
| 39 | Xalapa | 424,755 | Xalapa Municipality | Veracruz |
| 40 | Tonalá | 408,759 | Tonalá Municipality | Jalisco |
| 41 | Mazatlán | 381,583 | Mazatlán Municipality | Sinaloa |
| 42 | Irapuato | 380,941 | Irapuato Municipality | Guanajuato |
| 43 | Nuevo Laredo | 373,725 | Nuevo Laredo Municipality | Tamaulipas |
| 44 | Xico | 356,352 | Valle de Chalco Solidaridad Municipality | México |
| 45 | Villahermosa | 353,577 | Centro Municipality | Tabasco |
| 46 | General Escobedo | 352,444 | General Escobedo Municipality | Nuevo León |
| 47 | Celaya | 340,387 | Celaya Municipality | Guanajuato |
| 48 | Cuernavaca | 338,650 | Cuernavaca Municipality | Morelos |
| 49 | Tepic | 332,863 | Tepic Municipality | Nayarit |
| 50 | Ixtapaluca | 322,271 | Ixtapaluca Municipality | México |
